Samson's Snakeroot is an upright, hairy perennial. Its preferred habitat is dry sandy pinelands, sandy roadsides, and dry woods. Distribution is throughout the Escambia region.

The leaves are opposite on the stem, simple (no teeth and no lobes), clasping, elliptic, consisting of one whole part. The leaf tip is blunt (acute), with base wedge-shaped.

The flowers are mostly in a terminal cluster. The calyx is lobed. The corolla is tubular to funnel-form. The color is whitish-green or yellowish-green, and may have a tinge of purple; four to five stamens. Flowers occur in the summer.

Fruit is a capsule.